DNA’s ‘topography’ influences where cancer-causing mutations appear

DNA’s 3D form — its twisted ladders complexly curled into coils and loops — and different options past its genetic code could affect the place “hotspots” of cancer-causing mutations accumulate.

That is in response to a brand new examine of how “genomic topography” impacts most cancers mutations. Genomic topography broadly refers to parts of the genome past the sequence of molecules that make up DNA. That features variations in how tightly our DNA is wound and which genes are “activated” in numerous cells.